The Eshkol Regional Council (Hebrew: מועצה אזורית אשכול‎, Mo'atza Ezorit Eshkol) is a regional council in the north-western Negev, in Israel's Southern District. The regional council's territory lies midway between Ashkelon and Beersheba, bounded on the west by the Gaza Strip while the eastern border abuts the territory of the Bnei Shimon Regional Council.