Río Grande de Matagalpa (Spanish pronunciation: [mataˈɣalpa], Awaltara in Miskito) is a river of Nicaragua. Running 430 kilometers (270 mi) from its source near Matagalpa to the Caribbean Sea in the northern part of the South Caribbean Coast Autonomous Region it is the second longest river in Nicaragua. It gives it name to the city and municipality of La Cruz de Río Grande.