San Francisco de Cuapa (Spanish pronunciation: [sam fɾanˈsisko ðe ˈkwapa]) is a municipality in the Chontales Department of Nicaragua. This municipality was created July 30, 1997 and is located in the northeast section of Chontales. Before that date, the town was part of the municipality of Juigalpa. Its area is about 277 km² (107 sq mi). The principal business activity is the cattle and agriculture. 99% of the population is Catholic. The first mayor was Manuel Antonio Zelaya Meneses and the vice-mayor was Oscar Velasquez Gonzalez.