Sikeston /ˈsaɪkstən/ is a city located both in southern Scott County and northern New Madrid County, in the U.S. state of Missouri. It is situated just north of the "Missouri Bootheel", although many locals consider Sikeston a part of it. By way of Interstate 55, Interstate 57, and U.S. Route 60, Sikeston is close to the halfway point between St. Louis, Missouri and Memphis, Tennessee and three hours from Nashville, Tennessee.