Prairie Creek (also Middletown) is an unincorporated community in southeastern Prairie Creek Township, Vigo County, Indiana, United States. It lies at the intersection of State Roads 63 and 246 southwest of the city of Terre Haute, the county seat of Vigo County. Its elevation is 531 feet (162 m), and it is located at (39°16′30″N87°29′50″W) (39.2750390, -87.4972443).