Santa Fe High School is a high school serving grades 9–12 in the Alachua-High Springs area in northwestern Alachua County, Florida. It is part of the Alachua County Public Schools. The school mascot was originally the Rebels, but was later changed to the Raiders in 1970 when integration was implemented. The school colors are red and gray. Dr. Beth Leclear is the principal. Santa Fe also offers 15 Advanced Placement Courses leading to college credit. There is a unique program in the Academy of Agriscience.