Big Butte Creek is a 12-mile-long (19 km) tributary of the Rogue River in the U.S. state of Oregon. It drains approximately 245 square miles (635 km²) of Jackson County. Its two forks, the North Fork and the South Fork, both begin high in the Cascade Range near Mount McLoughlin. Flowing predominantly west, they meet near the city of Butte Falls. The main stem flows generally northwest until it empties into the Rogue River near McLeod, about one mile southwest of William L.