The Sisquoc River is a westward flowing river in northeastern Santa Barbara County, California. It is a tributary of the Santa Maria River, which is formed when the Sisquoc River meets the Cuyama River at the Santa Barbara County and San Luis Obispo County border just north of Garey. The river is 57.4 miles (92.4 km) long and originates on the north slopes of Big Pine Mountain, at approximately 6,320 feet (1,930 m).