The Cape Romain National Wildlife Refuge is a 66,287 acre (267 km²) National Wildlife Refuge in southeastern South Carolina near Awendaw, South Carolina. The refuge lands and waters encompass water impoundments, creeks and bays, emergent salt marsh and barrier islands. 29,000 acres (120 km²) are designated as Class I Wilderness. Most of the refuge is only accessible by boat. Mainland facilities include the refuge's headquarters and visitor center which are located on U.S.