The Big Four Bridge is a six-span former railroad truss bridge that crosses the Ohio River, connecting Louisville, Kentucky, and Jeffersonville, Indiana, United States. It was completed in 1895, and updated in 1929. The largest single span is 547 feet (167 m), with the entire bridge spanning 2,525 feet (770 m). It took its name from the defunct Cleveland, Cincinnati, Chicago and St. Louis Railway, which was nicknamed the "Big Four Railroad".