Upson-Lee High School is a secondary school in Thomaston, Georgia. It is the only high school in Upson County. It is a combination of the former R. E. Lee Institute and Upson High School, both previously located in Upson County. Upson-Lee High School serves 1284 students with a diverse and challenging selection of academic and elective courses, advanced placement and honors programs, sixteen CTAE (Career, Technical and Agriculture Education) pathways, Navy JROTC, and dual enrollment with Gordon College and Southern Crescent Technical College.