Little Butte Creek is a 17-mile-long (27 km) tributary of the Rogue River in the U.S. state of Oregon. Its drainage basin consists of approximately 354 square miles (917 km²) of Jackson County and another 19 square miles (49 km²) of Klamath County. Its two forks, the North Fork and the South Fork, both begin high in the Cascade Range near Mount McLoughlin and Brown Mountain. They both flow generally west until they meet near Lake Creek.