The North River is an 82-mile-long (132 km) river in northeastern Missouri, the United States. It rises in Knox County at approximately N40˚ 3' 30" W92˚ 15' 26" (northwest of Novelty) and flows southeast and east through Shelby and Marion counties, emptying into the Mississippi River between West Quincy and Hannibal. The North River drainage area is 373 square miles (970 km²), with a median flow of 38 cu ft/s (1.1 m³/s) and a mean flow of 231 cu ft/s (6.5 m³/s) based on 72 years of record at the USGS Palmyra gaging station. Record flow was on April 21, 1973 at 57,500 cu ft/s (1,630 m³/s).