The Hassayampa River (Yavapai: Hasaya:mvo or ʼHasayamcho:) is an intermittent river, the headwaters of which are just south of Prescott, Arizona, United States, and flows mostly south towards Wickenburg entering the Gila River near Hassayampa, Arizona. Although the river has only subsurface flow for much of the year, it has significant perennial flows above ground within the Hassayampa River Canyon Wilderness and the Nature Conservancy's Hassayampa River Preserve, near Wickenburg.