Sheldon is an unincorporated community in Beaufort County, South Carolina, United States, at latitude 32.602 and longitude -80.793. Sheldon is located approximately halfway between Beaufort and Yemassee and just east of Interstate 95 in the heart of the Lowcountry region. U.S. Highway 17 and U.S. Highway 21 run through the center of the community in a wrong-way concurrency.