Guyandotte is a historic neighborhood of Huntington, West Virginia and was formerly a small town in Virginia (and after 1863, West Virginia) located at the confluence of the Guyandotte River (which drains much of the more rugged portion of southern West Virginia) and the Ohio River. In 1873, when the Chesapeake and Ohio Railway (C&O) reached its western terminus there and built new facilities, the newly enlarged city was named Huntington, in honor of C&O Railway leader Collis P.