St. Francis Preparatory School, commonly known as St. Francis Prep, is a private, independent Catholic college preparatory school in the Fresh Meadows neighborhood of the New York City Borough of Queens, in the State of New York. It is the largest non-diocesan Catholic high school in the United States. St. Francis is run by the Franciscan Brothers of Brooklyn, who maintain a residence on the top floor of the school. The school has a student body of about 2,750 students and graduates between 600 and 700 students annually.