The Kishacoquillas Valley, known locally as both Kish Valley and Big Valley, is an enclosed anticlinal valley in the Ridge-and-valley Appalachians of Central Pennsylvania, lying between Stone Mountain ridge to the north and Jacks Mountain ridge to the south. The valley is located in Mifflin County and Huntingdon County. Many Amish and Mennonite people live in the valley. Kishacoquillas Valley is home to the Nebraska Amish, one of the most conservative Amish groups. The valley drains via the Kishacoquillas Creek through the Mann Narrows water gap in Jacks Mountain to the Juniata River. U.S. Route 322 follows the creek though the gap, and is the main travel route across the valley, running from Harrisburg to State College.