Yazoo City is a city in Yazoo County, Mississippi, United States. It was named after the Yazoo River, which, in turn was named by the French explorer Robert La Salle in 1682 as "Rivière des Yazous" in reference to the Yazoo tribe living near the river's mouth. It is the county seat of Yazoo County and the principal city of the Yazoo City Micropolitan Statistical Area, which is part of the larger Jackson–Yazoo City Combined Statistical Area.