Frystown is a census-designated place in Bethel Township, in far western Berks County, Pennsylvania. It is located near the township line with Tulpehocken Township. The community is served by the Tulpehocken Area School District. As of the 2010 census, the population was 380 residents. The Little Swatara Creek forms the natural southern boundary of Frystown and flows westward into the Swatara Creek, a tributary of the Susquehanna River. Interstate 78 has an interchange with Route 645 in Frystown. The CDP is split between the Myerstown and Bethel post offices, which use the zip codes of 17067 and 19507, respectively.