Sprankle Mills is a small unincorporated rural community in Jefferson County, Pennsylvania, United States. It is located between the boroughs of Punxsutawney and Brookville. Sprankle Mills was founded in 1833 by Frederick Sprankle who owned a mill in the middle of town. Primarily a farming community this town, in the mid-to-late 19th century, had two general stores, a post office and a one room school house. The post office, which was located in one of the general stores, was a working post office until the late 1980s. While the one-room school house is still standing it is primarily used as a gathering place for residents during occasions such as the first day of fishing season and on voting days.