Plymouth was an early settlement in Mississippi in present-day Lowndes County. Plymouth was located at (33°31′23″N88°30′06″W) on the west bank of the Tombigbee River. It was formed around 1819, nucleating at the fortified house of John Pitchlynn, the U.S. interpreter for the Choctaw Agency for communications with the Choctaw Nation. The low-lying landing site of the village was prone to repeated flooding. While both Plymouth and its sister town of Columbus across the river had high bluffs, Plymouth's landing site did not have easy access to the bluff heights.