Hereford is a census-designated place in Hereford Township, Berks County, Pennsylvania. The community lies at the intersection of Pennsylvania Routes 29 and 100, which connects it to East Greenville and to Pottstown, respectively to the south. They continue north on Chestnut Street to Shimerville in Lehigh County, where 29 continues toward Allentown. The Perkiomen Creek flows south through Hereford to the Schuylkill River.