The Galisteo Basin is a surface basin and a closely related groundwater basin in north-central New Mexico.  Its primary watercourse is the Galisteo River or Galisteo Creek, a perennial stream, for part of its course, that flows from the eastern highlands down into the Rio Grande about three miles above the Santo Domingo Pueblo. The Galisteo basin covers approximately 467,200 acres and runs from San Miguel County in the east, across Santa Fe County, and into Sandoval County at its westernmost point, the Rio Grande. Northeast of Galisteo Basin rise the Sangre de Cristo Mountains and to the southwest lie the Sandia Mountains.