Catlettsburg is a home rule-class city in and the county seat of Boyd County, Kentucky, United States. The city population was 1,856 at the 2010 census. Catlettsburg is a part of the Huntington-Ashland, WV-KY-OH, Metropolitan Statistical Area (MSA). As of the 2010 census, the MSA had a population of 287,702. Since the early 1990s, the commercial sector has grown due to its proximity to Interstate 64 and its location along U.S. Route 23 and 60, both major regional arteries which overlap in Catlettsburg and travel into the city of Ashland to the north.