Keokuk /ˈkiːəkʌk/ is a city in the southeastern part of the U.S. state of Iowa and one of the county seats of Lee County. The other county seat is Fort Madison. The population was 10,780 at the 2010 census. The city is named after the Sauk Chief Keokuk, who is thought to be buried in Rand Park. It is located in the extreme southeast corner of Iowa where the Des Moines River meets with the Mississippi. It is located at the junction of U.S.