North Uxbridge is a village, and post office, in the town, (township) of Uxbridge in Worcester County, Massachusetts, United States. The postal zip code is 01538. It is classified as a community or populated place (Class Code U6) located at latitude 42.088 and longitude -71.641 and the elevation is 266 feet (81 m). North Uxbridge appears on the Uxbridge U.S. Geological Survey Map. Worcester County is in the Eastern time zone (GMT -5) and observes DST. North Uxbridge is located about 36 miles WSW of Boston, and 15 miles SE of Worcester. The town meeting in 1885 set aside North Uxbridge as a "special district", since its population had exceeded 1000 people.