The Perquimans River is a coastal waterway in Northeastern North Carolina in the United States. Located entirely within Perquimans county, the river drains directly to the Albemarle Sound between Durant's Neck on the north and Harvey Neck on the south. It is a tidal estuary to just north of the towns of Hertford and Winfall. Because of the extremely flat topography of the region, the Perquimans flows quite slowly and has cypress swamps on either bank for much of its upper length. It has its headwaters in the swampy region or northern Perquimans and southern Gates counties.