Mebane /ˈmɛbən/ is a city located mostly in Alamance County, North Carolina, United States, with a part of it in Orange County, North Carolina. The town was named for General Alexander Mebane, Jr., a Revolutionary War general and member of the U.S. Congress. It was incorporated as Mebanesville in 1881 and in 1883 the name was changed to Mebane.