Gaffney is a city in and the county seat of Cherokee County, South Carolina, United States, in the upstate region of South Carolina. Gaffney is known as the Peach Capital of South Carolina. The population was 12,414 at the 2010 census. It is the principal city of the Gaffney, South Carolina, Micropolitan Statistical Area (population 55,662 according to year 2012 estimates by the U.S. Census Bureau), an MSA which includes all of Cherokee County and which is further included in the greater Greenville-Spartanburg-Anderson, South Carolina Combined Statistical Area (population 1,384,996 according to year 2012 U.S.