Syamzha (Russian: Сямжа) is a rural locality (a selo) and the administrative center of Syamzhensky District of Vologda Oblast, Russia, located on both banks of the Syamzhena River, a tributary of the Kubena River. It also serves as the administrative center of Syamzhensky Selsoviet, one of the ten selsoviets into which the district is administratively divided. Municipally, it is the administrative center of Syamzhenskoye Rural Settlement.