Velika Drenova (Serbian: Велика Дренова) is a village of about 5,000 inhabitants in Trstenik municipality, Rasina District, Serbia. It is located on the Zapadna Morava River in the central Serbian area of Šumadija. Velika Drenova is the biggest producer of vine in Serbia and vinegrapes are a major export. Velika Drenova is also known by its grafters which is heard about all over the world.