Macuspana is a city in Macuspana Municipality in the south-central part of the state of Tabasco in southeastern Mexico. The city of Macuspana had a 2005 census population of 30,661 and is the fifth-largest city in the state. It is the municipal seat of the municipality of Macuspana, which has an area of 2,551.7 km² (985.22 sq mi) and a population of 142,954, which includes numerous smaller communities.