San Pablo de Mitla is a town and municipality in Mexico which is most famous for being the site of the Mitla archeological ruins. It is part of the Tlacolula District in the east of the Valles Centrales Region. The town is also known for its handcrafted textiles, especially embroidered pieces and mezcal. The town also contains a museum which was closed without explanation in 1995, since when its entire collection of Zapotec and Mixtec cultural items has disappeared.