The municipality of Tlaltenango de Sánchez Román is located in the southwestern portion of the Mexican state of Zacatecas. The average elevation of the municipality is 1,723 meters (5,653 ft) above sea level and the municipality covers an area of 747.082 square kilometres (288.450 sq mi). The municipality lies in a valley bordered by the Sierra de Morones and lies on the banks of the Tlaltenango River, which runs north and is a tributary of the Bolaños River.