Palazzo Datini is a building in Prato, Tuscany central Italy. Begun in 1383 as the residence of merchant Francesco Datini, it was subsequently decorated by some of the most notable artists of that age, such as Agnolo Gaddi and Niccolò di Pietro Gerini, both internally and on the exterior, although the latter paintings are rather damaged. It once included, in front of the current façade, a botanical garden which was among the first ones in Italy. In 1409 the Datini housed here Pope Alexander V and Louis II of Anjou, King of Naples.