Tyrnavos (Greek: Τύρναβος, from the Slavic Tirnovo, a "thorny place") is a municipality in the Larissa regional unit, of the Thessaly region of Greece. It is the second largest town of the Larissa regional unit, after Larissa. The town is near the mountains and the Thessalian Plain. The river Titarisios, a tributary of the Pineios, flows through the town. Tyrnavos is bypassed by the GR-3 (Larissa - Kozani - Niki) and has an old road connecting the town to Elassona. It will be linked with a superhighway numbered 3 (A3) with an unscheduled opening date.