Melissani Cave (Greek: Μελισσάνη) or Melissani Lake, also Melisani is a cave located on the island of Kefalonia, northwest of Sami, about 5 km SE of Agia Efthymia, NE of Argostoli and NW of Poros. The Ionian Sea lies to the east with the Strait of Ithaca. Forests surrounds the cave and the mountain slope is to the west.