The A49 is an A road in western England, which traverses the Welsh Marches region. It runs north from Ross-on-Wye in Herefordshire via Hereford, Leominster, Ludlow, Shrewsbury and Whitchurch, then continues through central Cheshire to Warrington and Wigan before terminating at its junction with the A6 road just south of Bamber Bridge, near the junction of the M6, M65 and M61 motorways.