The River Glyme is a river in Oxfordshire, England. It is a tributary of the River Evenlode. It rises about 1 mile (1.6 km) east of Chipping Norton, and flows southeast past Old Chalford, Enstone, Kiddington, Glympton and Wootton, Woodstock and through Blenheim Park. At Wootton the Glyme is joined by a tributary, the River Dorn.