Medebay Zana is one of the woredas in the Tigray Region of Ethiopia. Part of the Semien Mi'irabawi Zone, Medebay Zana is bordered on the south by the Tekezé River which separates Tahtay Adiyabo from Tselemti, on the southwest by Asigede Tsimbela, on the northwest by Tahtay Koraro, on the north by La'ilay Adiyabo, and on the east by the Mehakelegnaw (Central) Zone.