La'ilay Maychew (Tigrinya: "Upper Salty Water") is a woreda in the Tigray Region of Ethiopia. Part of the Mehakelegnaw Zone, La'ilay Maychew is bordered on the south by Naeder Adet, on the west by Tahtay Maychew, on the north by Mereb Lehe, and on the east by Adwa.