Saesi Tsaedaemba (Ge'ez: ሳዕሲዕ ጻዕዳ እምባ) is one of the woredas in the Tigray Region of Ethiopia. Located in the Misraqawi Zone at the eastern edge of the Ethiopian highlands, Saesi Tsaedaemba is bordered on the south by Kilte Awulaelo, on the southwest by Hawzen, on the west by Ganta Afeshum, on the northwest by Gulomahda, on the north by Irob, on the east by the Afar Region, and on the southeast by Atsbi Wenberta.