Mayabeque River (alternately Rio Mayabeque) is a river of western Cuba, considered the largest in the southwestern watershed of Cuba, with an extensive fluvial network that encompasses the municipalities of Güines, San Jose de las Lajas, Jaruco, Madruga, and Melena del Sur. The old outlet in Melena del Sur (now connected with the main river only by irrigation canals) is named Antiguo Mayabeque.