Hughson Street is a Lower City collector road in Hamilton, Ontario, Canada. It starts at Charlton Avenue East at St. Joseph's hospital and runs north to Haymarket Street in the downtown where it's cut off by the Hamilton GO Transit station. Up to this point it is a two-way street. It then starts up again north of the station on Hunter Street East, where it then becomes a one-way street going north just past Barton Street East to Murray Street where it's cut off again by a parking lot for LIUNA Station.