Tupiza is a city in Potosí Department, Bolivia. It is located at an elevation of about 3160 m. The population is 25,709 (2012 estimate). Tupiza and its environs are characterized by dramatic red escarpments which jut ruggedly skyward from the coarse, gray terrain; green agricultural land adjacent to the Tupiza River provides welcome respite from the otherwise arid, thorny surroundings.