Panagyurishte (Bulgarian: Панагюрище, international transliteration Panagyurishte) is a town in Pazardzhik Province, Southern Bulgaria, situated in a small valley in the Sredna Gora mountains. It is 91 km east of Sofia, 43 km north of Pazardzhik, and 37 km south of Zlatitsa. The town is the administrative centre of the homonymous Panagyurishte Municipality.