Qashqadaryo Region (Uzbek: Qashqadaryo viloyati, Қашқадарё вилояти), (old spelling Kashkadarya Region) is one of the regions of Uzbekistan, located in the southern part of the country in the basin of the Qashqadaryo River and the western slopes of the Pamir Mountains. It borders with Tadjikistan, Turkmenistan, Samarqand Region, Bukhara Region and Surxondaryo Region. It covers an area of 28,400 km². The population is estimated to be around 2,067,000 (2007), with some 73% living in rural areas.