Wynantskill is a hamlet and census-designated place (CDP) in Rensselaer County, New York, United States. The population was 3,276 at the 2010 census. Wynantskill is located at the north town line and the northeast corner of the town of North Greenbush. The community is a suburb of Troy. NY Route 66 (Pawling Ave. in Troy, Main Ave. in Wynantskill) is the main route throughout the community. Wynantskill has a major grocery store, several banks, restaurants, convenience stores, a post office, and a bowling alley, with almost all houses located on side streets off Main Ave.