Manning is a city in South Carolina and the county seat of Clarendon County in the Southeastern United States, located in the center of the county, just to the east of Interstate 95 and at the intersection of U.S. 301 and U.S. 521. The population was estimated to be 4,000 as of 2013, down 2% from its 4,025 population as of the 2000 census.